Proxodolol--a new beta- and alpha-adrenoblockader
Iuzhakov, S.D.; Dolgun, O.V.; Dorodnikova, E.V.; Aniukhovskiĭ, E.P.; Baldenkov, G.N.; Rozenshtraukh, L.V.; Medvedev, O.S.; Mashkovskiĭ, M.D.
Eksperimental'naia i Klinicheskaia Farmakologiia 57(3): 30-33
1994
ISSN/ISBN: 0869-2092 PMID: 7914115 Document Number: 430916
The beta- and alpha-adrenoceptor blocking activity, the specificity of its beta-adrenoceptor blocking action, partial agonistic and membrane-stabilizing properties, as well as antihypertensive, antiarrhythmic, and anti-ischemic effects were studied. Proxodolol was shown to be superior to labetalol in its beta-adrenoceptor blocking action and similar to it in its alpha-adrenoceptor blocking agent. The drug has no a partial agonistic activity and produces a moderate membrane-stabilizing action. Proxodolol proved to be effective in treating experimental hypertension and arrhythmias. It exhibits anti-ischemic activity.