Cardio-hemodynamic effects of domestic adrenergic beta-antagonist proxodolol in hypertension in patients with pacemaker
Iskenderov, B.G.; Tatarchenko, I.P.; Shevyrev, V.A.
Klinicheskaia Meditsina 77(4): 29-31
1999
ISSN/ISBN: 0023-2149 PMID: 10356914 Document Number: 512113
59 patients with mild and moderate essential hypertension have received a course treatment with beta-adrenoblocker proxodolol. The latter was studied for a hypotensive action and cardiohemodynamic effects as regards baseline type of circulation and pacing regimen. Proxodolol hypotensive action in hyperkinetic circulation is attributed primarily to a fall in the ejection (beta-adrenoblock), in hypo- and eukinetic circulation type--to reduction in cardiac postload (alpha-adrenoblock). In isolated ventricular stimulation proxodolol cardiodepressive effect was more pronounced than in atrial stimulation. An overall hypotensive effect of proxodolol in mild arterial hypertension made up 77.2%, in moderate--66.5%.