Liver injury due to verapamil
Burgunder, J.M.; Abernethy, D.R.; Lauterburg, B.H.
Hepato-Gastroenterology 35(4): 169-170
1988
ISSN/ISBN: 0172-6390 PMID: 3181862 Document Number: 4309
A 56-year-old female patient on verapamil for hypertension experienced two episodes of jaundice, pruritus and upper abdominal pain with transaminase elevated up to six-fold and alkaline phosphatase up to four-fold when inadvertently re-challenged with the drug. Liver biopsy showed marked cholestasis. Verapamil can occasionally cause mixed cytotoxic-cholestatic liver injury.
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