A new biological activity for the neuropeptide FMRFamide: experimental evidence for a secretagogue effect on amylase secretion in the scallop Pecten maximus
Favrel, P.; Giard, W.; Benlimane, N.; Boucaud-Camou, E.; Henry, M.
Experientia 50(11-12): 1106-1110
1994
ISSN/ISBN: 0014-4754 PMID: 7527347 Document Number: 430626
FMRFamide immunoreactivity in the digestive tract of the bivalve mollusc Pecten maximus was investigated by immunocytochemistry. Positive FMRFamide-like immunoreactivity was detected in nerve fibres in close contact with exocrine alpha amylase secreting cells. Physiological studies on enzymatically dissociated cells of the stomach-digestive gland complex demonstrated the involvement of FMRFamide and analogues in the control of alpha amylase release from the cells. The FMRFamide-induced secretion was shown to be time- and dose-dependent. In contrast to most naturally occurring vertebrate secretagogues which are hormones, FMRFamide appears to work in our in vitro system as a paracrine factor.