Effect of nicotine on gastric acid secretion: evidence of electrogenic pump theory
Dinno, M.A.; Ando, M.; Dinno, F.H.; Huang, K.C.; Rehm, W.S.
American Journal of Physiology 232(3): E251-E257
1977
ISSN/ISBN: 0002-9513 PMID: 14510 Document Number: 110830
In vitro studies on H+ secretion, potential difference (PD), short-circuit current (Isc) and resistance across stripped mucosa of frog of the Cl- pump on the mucosal membrane and of the Cl- gradient across the serosal membrane, i.e., ECl + E'Cl, was 35 mV. The presence of such linear relationships between measured PD vs. the H+ rate and Isc vs. IH lent support to the electrogenic theory of HCl secretion.