The effect of antral acidification on bile-induced gastric acid secretion
Nahrwold, D.L.; Rose, R.C.; Kaminski, D.L.
Surgery 74(3): 315-320
1973
ISSN/ISBN: 0039-6060 PMID: 4722696 Document Number: 66706
Cannulated denervated antral pouches in 4 dogs were perfused at a rate of 1.0 ml/min with either acetylcholine chloride in 250 mM glycine solution, 5.0 mM sodium glycocholate in NaCl solution, or 5.0 mM bile salt in NaCl solution, each at varying pH 1 to 7, and gastric secretion was collected from Heidenhain pouches. All substances induced increased acid secretion. The response to bile salt was similar to that with glycocholate, and acetylcholine was about 3 times as effective in stimulating secretion as the other two. Maximum secretion was obtained when the perfusate was between pH 3 and 7 in each case, and was low at pH 1 to 2. Effluent from antral pouches was at the original pH when the latter was low, became more variable with higher pH, but the mean was reduced only when the perfusate was at pH 7. The possible relevance to stimulation of gastric acid secretion in man, particularly in patients with stress ulcers and after certain operations, was discussed.