4-Aminopyridine-induced licking response and histamine liberation in mice
Lin, Y.H.; Xu, J.H.
Zhongguo Yao Li Xue Bao 15(3): 249-252
1994
ISSN/ISBN: 0253-9756 PMID: 7526601 Document Number: 430098
4-Aminopyridine (4-AP) 1 mg cntdot kg-1 sc at the scruff induced a licking response in mice. H-1 receptor blockaders, such as diphenhydramine HC1 (1, 10 mg cntdot kg-1, sc at the scruff or 40 mg cntdot kg-1, ip), chlorphenamine maleate (20 mg cntdot kg-1, ip), and astemizole (2 mg cntdot kg-1, ig), inhibited the licking response caused by 4-AP. Repeated injected of 4-AP (1 mg cntdot kg-1) reduced the times of lick and the histamine content in the skin of injected site. 4-AP also promoted histamine release from incubation mouse peritoneal mast cells (PMC) in a dose-dependent manner. The results indicate that the licking response may originate from the histamine liberation of mast cells.