The mechanism of histamine liberation from rat mast cells under the action of x-ray contrast media
Napolov, I.K.
Eksperimental'naia i Klinicheskaia Farmakologiia 60(1): 53-55
1997
ISSN/ISBN: 0869-2092 PMID: 9162287 Document Number: 478994
It was demonstrated in rat experiments that a positive direct correlation exists between the decrease in the amount of histamine in rat peritoneal must cells after intravenous infusion of radiopaque agents (ROA) in a dose of 2 ml/kg and the amount of these penetrating from the blood into the peritoneal cavity. The degree of penetration is determined by the chemical structure and/or physiochemical properties of the ROA.
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