Effect of dopamine and prostaglandin E1 on portal venous oxygenation
Hayakawa, J.; Itoh, T.; Kanemura, K.; Shibata, T.; Usuda, Y.
Masui. Japanese Journal of Anesthesiology 43(5): 684-688
1994
ISSN/ISBN: 0021-4892 PMID: 8015155 Document Number: 429918
We evaluated the effects of dopamine (DA) and PGE-1 on portal venous oxygenation in patients undergoing gastrectomy. Thirty-two patients studied were anesthetized with isoflurane and nitrous oxide in oxygen. They were divided into three groups: DA was infused at a rate of 3 mu-g cntdot kg-1 cntdot min-1 in 10 patients (DA group), PGE-1 was infused at a rate of 0.02 mu-g cntdot kg-1 cntdot min-1 in 10 patients (PGE-1 group), and the remainders did not receive DA nor PGE-1 (control group) There were no significant differences in Pa-O2 and Sa-O2 among three groups. However, portal venous PO-2 and SO-2 in DA and PGE-1 group were significantly higher than those in the control group. These results suggest that DA and PGE-1 elevate the portal venous PO-2 and SO-2 by increasing splanchnic blood flow more than its oxygen uptake or without increasing splanchnic oxygen uptake, and increase the oxygen supply to the liver.