The effects of prostaglandin E1 on systemic and cerebral oxygenation before and during cardiopulmonary bypass
Kawahara, F.; Kadoi, Y.
Masui. Japanese Journal of Anesthesiology 51(2): 128-133
2002
ISSN/ISBN: 0021-4892 PMID: 11889777 Document Number: 545972
The purpose of this study was to examine the effects of a small dose of prostaglandin E1 on systemic and cerebral oxygenation. Thirty patients for coronary artery bypass graft surgery were randomly divided into two groups: Group 1 received PGE1 25 ng cntdot kg-1 cntdot min-1. Group 2 received PGE1 50 ng cntdot kg-1 cntdot min-1. After measuring baseline hemodynamics and mixed (Svo2) and juglar (Sjvo2) venous oxygen saturations, administration of PGE1 at a rate of 25 ng cntdot kg-1 cntdot min-1 or 50 ng cntdot kg-1 cntdot min-1 was started before and during CPB. In group 2, mean arterial pressure (MAP) decreased during CPB, while in group 1, MAP was unchanged during CPB. There was no change in Sjvo2 both in group 1 and group 2 before and during CPB. The administration of PGE1 at a rate of 25 ng cntdot kg-1 cntdot min-1 during CPB was suitable for the maintenance of Svo2 and Sjvo2.