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Experimental studies of the influence of priming solutions on the systemic activation of complement during cardiopulmonary bypass: comparison between the use of albumin, hydroxyethyl starch and HWA-138

Bunk, A.; Dapper, F.; Hata, H.; Neuhof, H.; Hehrlein, F.W.

Journal of Cardiovascular Surgery 34(2): 115-122

1993

ISSN/ISBN: 0021-9509
PMID: 7686550
Document Number: 408026
Cardiopulmonary bypass surgery may be complicated by a systemic inflammatory reaction, which has been ascribed to activation of complement. For such activation, the choice of priming solution for the heart-lung machine may be of importance. The peripheral blood of three groups of eight donors was exposed to albumin, hydroxyethyl starch (HES) or to HWA-138 (pentoxifylline analogue) in addition to the priming solutions. The study confirmed that activation of complement is a consistent phenomenon during cardiopulmonary bypass surgery. The concentration of the C-3 activation product C-3a in the plasma was significantly increased after simulated extracorporeal circulation. However, there were no differences within the increase of C-3a concentrations between the various priming solutions.

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