Demonstration os isoagglutinins in intravenously applicable immunoglobulin preparations
Strobel, E.; Wüllenweber, J.; Peters, J.
Beitrage Zur Infusionstherapie und Transfusionsmedizin 32: 200-202
1994
ISSN/ISBN: 1023-2028 PMID: 9480087 Document Number: 428567
Intravenous immunoglobulins (IvIg) contain not only the declared antibodies against pathogenic microorganisms but also all the other antibodies of the blood donors, e.g. against erythrocytic antigens. We tested 14 IvIg from 7 manufacturers (together 40 charges) for isoagglutinins and irregular blood group antibodies. To ameliorate the reading of our tests we used the gel-centrifugation method (ID-Microtyping System, Fa. Diamed, Bensheim, FRG). Isoagglutinins in the IvIg can influence blood group serologic tests. Therefore we point to the potential danger of misinterpretation of a positive direct antiglobulin test. In rare cases, hemolytic reactions after administration of high doses of IvIg might occur.