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Removal of biologically active admixtures from immunoglobulin preparations

Blokhina, I.N.; Kiseleva, I.A.; Anastasiev, V.V.; Savkina, M.A.

Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2: 65-68

1985

ISSN/ISBN: 0372-9311
PMID: 3887816
Document Number: 258272
Inclusion of an additional treatment of the products obtained at centrifugation stages b1 and b13 with activated bentonite and aluminium hydroxide into the alcohol method for the production of immunoglobulin from placental and abortion blood permits obtaining preparations with lowered content of proteolytic enzymes and thermostable acid phosphatase, free from chorionic gonadotropin and blood pigment. The treatment of the final preparation with DEAE cellulose removes blood group antigens from immunoglobulins. The preparations obtained by this method have been shown to meet the requirements for immunoglobulins imposed by technological specifications.

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