Admixtures present in antitoxic horse sera and pepsin preparations
Trubitsina, V.I.; Urykova, V.A.; Chernobel', T.P.; Noskova, V.V.; Panina, N.P.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 4: 95-101
1979
ISSN/ISBN: 0372-9311 PMID: 87071 Document Number: 148307
Antitoxic therapeutic sera produced by the method "Diaferm-3" (devised at the Institute of Epidemiology and Microbiology of the USSR Academy of Medical Sciences) are contaminated in the process of production with group-specific substances and extraneous enzymes contained in crude preparations of swine pepsin. These ballast substances have a negative influence on the process of purification and the stability of antitoxin during the storage of the sera and constitute one of the reasons of their high reactogenicity.