Successful neoadjuvant chemotherapy in a patient with advanced gastric cancer with multiple liver metastases
Tsuzuki, H.; Niki, M.; Ueda, H.; Takamoto, Y.; Oohara, M.; Mori, K.; Igarashi, S.; Osada, H.; Nishimura, G.; Kurosu, Y.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 21(10): 1655-1657
1994
ISSN/ISBN: 0385-0684 PMID: 8060142 Document Number: 426150
We described a case of advanced gastric cancer with multiple liver metastases, who was placed on neoadjuvant chemotherapy using CDDP and 5-FU (FP therapy) with a marked reduction in tumor load. The case was a 67-year-old male, who was admitted with a Borrmann III type advanced gastric cancer with multiple liver metastases. FP chemotherapy was carried out two times as neoadjuvant chemotherapy. As a result, both primary cancer and the metastatic tumors showed a remarkable reduction. Then, total gastrectomy with combined resections of spleen and transverse colon was done, and a reservoir was inserted into the hepatic artery. Postoperatively, intrahepatic arterial infusion of CDDP with oral administration of 5-FU was done in the outpatient clinic for about eleven months. But thirteen months later, he died from the rapid recurrence of the tumor.