Initial chemotherapy with an age-adjusted CHOP-schedule in non-Hodgkin lymphomas with unfavorable prognosis. a study of the I.G.C.i
Heinz, R.; Pawlicki, M.; Losonczy, H.; Varbiro, M.; Benedek, S.; Konopka, L.; Krc, I.; Brugiatelli, M.
Haematologica 71(6): 473-479
1986
ISSN/ISBN: 0390-6078 PMID: 3104156 Document Number: 4259
Seventy-eight non-Hodgkin lymphoma (NHL) patients were treated immediately after clinical staging with an age-adjusted CHOP-schedule. Histologic subtypes according to the Kiel-classification were the following: centrocytic large cell type: 11 patients; centroblastic: 29 patients; immunoblastic: 18 patients; lymphoblastic: 9 patients; NHL high grade unclassified: 11 patients. Extranodal involvement was observed in 35 patients. Localized extranodal disease was seen in 12. Overall response rate was 85%. Relapses were seen in 12 of 42 complete responders after 2 - 19 months (mean time till relapse 7 months). Factors significantly influencing prognosis were response to the therapy (p<0.0001), Karnofsky status (p<0.0002), B-symptoms (p<0.001), LDH (p<0.002), clinical stage according to Ann Arbor criteria (p<0.004), blood sedimentation rate (p<0.004). Histologic subtypes according to the Kiel-classification, age and sex did not influence prognosis significantly. We did not observe increased toxicity in unselected elderly patients, which might be attributed to our dosage adjustment.
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