Effect of nifedipine on T wave in ischemic myocardium
Wang, S.; Shen, X.; Li, X.; Huang, N.; He, X.
Hua Xi Yi Ke da Xue Xue Bao 25(3): 284-287
1994
ISSN/ISBN: 0257-7712 PMID: 7896245 Document Number: 425033
Calcium antagonists are generally considered to have no substantial effect on repolarization of the myocardium, so they have no direct effect on T wave, either. But in a pig model of myocardial ischemia, intracoronary nifedipine was found to reverse the inverted T wave induced by ischemia to upright promptly. Ten pigs were anesthetized with the chest opened, anterior interventricular branch of left coronary artery (LAD) was narrowed to 4.67 kPa of LAD pressure, and then adenosine or nifedipine was infused into the coronary respectively. During the 9 minute ischemia, intracoronary adenosine or intracoronary nifedipine got the similar HR, LVEDP, LVDP, CAP, CAQ, and the intracoronary adenosine even got higher CAQ than the intracoronary nifedipine did. However, the T wave was retained inverted during the adenosine infused, but during the intracoronary nifedipine, the inverted T wave was promptly turned upright. The relevant factors and mechanisms are discussed.