Effect of sodium oxybutyrate on the blood supply and activity of the normal and ischemic myocardium
Chichkanov, G.G.; Bogolepov, A.K.; Tsorin, I.B.; Matsievskiĭ, D.D.
Biulleten' Eksperimental'noi Biologii i Meditsiny 93(3): 44-47
1982
ISSN/ISBN: 0365-9615 PMID: 7093482 Document Number: 186255
It was shown in experiments on cats anesthesized with nembutal that sodium hydroxybutyrate given in doses of 100 and 200 mg/kg increases the coronary blood flow in the intact myocardium. At the same time oxygen consumption by the heart rises to a far less degree. The drug provokes negligible hypertension, raises the systolic and cardiac outputs, and enhances myocardial contractility. It was discovered in experiments on dogs with the ischemized heart that sodium hydroxybutyrate in a dose of 200 mg/kg increases the blood supply both to the intact and ischemized myocardium areas. Changes in myocardial ischemia duration and in the hemodynamics produced by sodium hydroxybutyrate are similar to those caused by the drug in experiments with the intact heart.