Effects of sodium oxybutyrate on the level of catecholamines and serotonin and monoamine oxidase activity in patients with alcoholism
Treskov, V.G.; Krashkina, I.I.; Tsirenina, M.L.; Koltovaia, N.A.; Nikol'skaia, G.V.; Baturin, A.K.; Gapparov, M.M.; Mel'nik, E.I.; Maĭskiĭ, A.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 108(7): 62-64
1989
ISSN/ISBN: 0365-9615 PMID: 2804304 Document Number: 342259
Sodium salt of gamma-hydroxybutyric acid (Na-GHB) was administered to 37 drug-free alcoholic men in placebo controlled study. The psychotropic effect was evaluated using psychometric scale of 4 ranges. Changes in plasma levels of epinephrine, norepinephrine, dopamine, serotonin and platelet MAO-B activity were assessed. The psychotropic effect was observed in 27 (76%) patients. The baseline of dopamine concentration was significantly correlated with the expression of psychotropic effect. Na-GHB decreased dopamine concentration in responders. The possible involvement of dopaminergic system in the realization of psychotropic effect of Na-GHB was discussed.