Regional alterations in the monoamine levels, monoamine oxidase activity and neurobehavioural effects in rats treated with Dimecron (phosphamidon)
Naqvi, S.M.; Hasan, M.
Indian Journal of Medical Research 94: 71-75
1991
ISSN/ISBN: 0019-5340 PMID: 2071188 Document Number: 370196
Monoamine levels, MAO activity and neurobehavioral perturbations were studied in albino rats intoxicated with Dimecron i.e., phosphamidon (2.0 mg/kg b wt, ip x 7 days). Open field behaviour (OFB) of the rats was examined thrice a day for seven days. Significant depletion in DA, NE and 5-HT, and enhancement of MAO were found in various regions of the central nervous system (CNS) on the 7th day. Daily decrease was observed in ambulation, rearing and preening responses, with maximum decrement on the seventh day of Dimecron intoxication.