Effect of serotonin and monoamine oxidase inhibitors on corneal anesthesia produced by celnovocaine and novocaine
Kalninia, I.E.; Baumanis, E.A.; Mikazhans, V.D.; Fateev, V.A.; Baltkaĭs, I.I.
Farmakologiia i Toksikologiia 40(4): 393-397
1977
ISSN/ISBN: 0014-8318 PMID: 902735 Document Number: 114182
In experiments on guinea pigs it is shown that a preliminary intraperitoneal administration of monoamine oxidase inhibitors (MAOI) -- transamine (10 mg/kg) or malic acid benzyldihydrazide (50 mg/kg) antagonizes the local anesthetic action of celnovocaine (CC) and novocaine (NC). An analogous effect is also observed following instillation of transamine (a 0.1% solution) and malic acid benzyldihydrazide (a 0.23% solution) into the eye 10 minutes before administration of the anesthetic. Instillation of a 0.1% serotonin creatinine sulphate solution also antagonizes anesthesia produced by CC and NC, while MAOI potentiates the effect of serotonin.