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Inhibition of liquefaction and protein degradation in human semen by gossypol

Vongsorasak, L.; Svasti, J.

International Journal of Andrology 8(6): 472-483

1985

ISSN/ISBN: 0105-6263
PMID: 3835162
DOI: 10.1111/j.1365-2605.1985.tb00860.x
Document Number: 424707
The liquefaction of freshly ejaculated human semen was delayed by gossypol. Liquefaction is normally accompanied by an autolytic degradation of semen proteins, and prior incubation with gossypol can inhibit factors (presumably proteinases) present in seminal plasma that degrade semen proteins. The possible consequences of this inhibition are discussed in relation to the proposed use of gossypol as a vaginal contraceptive.

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Toots, U.E.; Kel've, M.B.; Saarma, M.I. 1988: Degradation of messenger RNA, ribosomal RNA and 2-5A-dependent inhibition of protein biosynthesis Molekuliarnaia Biologiia 22(6): 1473-1481
Poole, B.; Ohkuma, S.; Warburton, M.J. 1977: The accumulation of weakly basic substances in lysosomes and the inhibition of intracellular protein degradation Acta Biologica et Medica Germanica 36(11-12): 1777-1788
Williams, M.A.; Smith, D.C. 1996: RNA and protein synthesis in the nonspermatozoal cells of normal human semen Journal of Anatomy 188: 137-147
Kalla, N.R.; Gadru, N.; Foo, T.W. 1986: Studies on the male antifertility agent gossypol acetic acid. VII. Effect of motility stimulated factors on the revival of human spermatozoal motility after gossypol treatment in vitro Andrologia 18(4): 393-397
Kedar, I.; Sohar, E.; Ravid, M. 1982: Degradation of amyloid by a serum component and inhibition of degradation Journal of Laboratory and Clinical Medicine 99(5): 693-700
Kurzrok, R.; Lieb, C. C. 1930: Biochemical Studies of Human Semen. II. The Action of Semen on the Human Uterus Experimental Biology and Medicine 28(3): 268-272
Davies, K.J. 1985: Free radicals and protein degradation in human red blood cells Progress in Clinical and Biological Research 195: 15-27
Podobed, O.V.; Golubeva, N.V.; Kukharenko, V.I.; Del'vig, A.A. 1988: Kinetics of protein degradation in diploid and trisomic human fibroblasts Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 1988(5): 41-45
Kalla, N.R.; Vasudev, M. 1981: Studies on the male antifertility agent-gossypol acetic acid. II. Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa Andrologia 13(2): 95-98
Bohley, P.; Miehe, C.; Miehe, M.; Ansorge, S.; Kirschke, H.; Langner, J.; Wiederanders, B. 1972: Intracellular protein degradation. V. Preferred degradation of short life cytosol proteins by lysosomal endopeptidases from the rat liver Acta Biologica et Medica Germanica 28(2): 323-330
Medrano, E.E.; Im, S.; Yang, F.; Abdel-Malek, Z.A. 1995: Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1/SDI-1/Cip-1 protein Cancer Research 55(18): 4047-4052
Singer, R.; Sagiv, M.; Barnet, M.; Levinsky, H. 1990: Semen volume and fructose content of human semen. Survey of the years 1980-1989 Acta Europaea Fertilitatis 21(4): 205-206
Lu, W-Hong.; Gu, Y-Qun. 2010: Insights into semen analysis: a Chinese perspective on the fifth edition of the WHO laboratory manual for the examination and processing of human semen Asian Journal of Andrology 12(4): 605-606
Lu, W-Hong.; Gu, Y-Qun. 2010: Insights into semen analysis: a Chinese perspective on the fifth edition of the WHO laboratory manual for the examination and processing of human semen Asian Journal of Andrology 12(4): 605-606
Reinstein, E. 2004: The ubiquitin system for intracellular protein degradation--involvement in human pathologies and therapeutic implications Harefuah 143(8): 605-608; 621, 620
Sakhibov, A.D.; Sokolova, S.F.; Mirsalikhova, N.M. 1986: Mechanism of Na,K-ATPase inhibition with gossypol and megasin Voprosy Meditsinskoi Khimii 32(3): 111-115
Juhl, P.; Thudium, C.S.; Gudmann, N.S.; Karsdal, M.A.; Bay-Jensen, A.-C.; Siebuhr, A.S. 2018: IL-6 receptor inhibition modulates type IIi collagen and C-reactive protein degradation in rheumatoid arthritis patients with an inadequate response to anti-tumour necrosis factor therapy: analysis of connective tissue turnover in the tocilizumab RADIATE study Clinical and Experimental Rheumatology 36(4): 568-574
Ikeda, M. 1990: Inhibition kinetics of NAD-linked enzymes by gossypol acetic acid Andrologia 22(5): 409-416
Wang, M.S.; Lorenzo, B.J.; Reidenberg, M.M. 1997: NAD- and NADP-dependent 11 beta-hydroxysteroid dehydrogenase isoforms in guinea pig kidney with gossypol inhibition Zhongguo Yao Li Xue Bao 18(6): 481-485
Ryes, J.; Wyrick, S.D.; Borriero, L.; Benos, D.J. 1985: The male contraceptive gossypol membrane actions of the gossypol tautomers Biophysical Journal 47(2 Part 2): 479A