Mechanism of Na,K-ATPase inhibition with gossypol and megasin
Sakhibov, A.D.; Sokolova, S.F.; Mirsalikhova, N.M.
Voprosy Meditsinskoi Khimii 32(3): 111-115
1986
ISSN/ISBN: 0042-8809 PMID: 3014735 Document Number: 282960
Kinetic patterns of megosin and gossypol effects on properties of highly purified Na+, K+-ATPase were studied. Inhibition of the enzymatic activity appears to occur due to interaction of these compounds with the enzyme probound to the intracellular side of the transport enzyme.
Document emailed within 1 workday
Related Documents
Kalla, N.R.; Vasudev, M. 1981: Studies on the male antifertility agent-gossypol acetic acid. II. Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa Andrologia 13(2): 95-98Ye, Y.X.; Bi, X.F.; Zheng, Y.J.; Yang, H.F. 1986: Mode of inhibitory action of gossypol on Na+, K+-ATPase in vitro Zhongguo Yao Li Xue Bao 7(3): 265-268
Ye, Y.X.; Bi, X.F.; Zheng, Y.J.; Yang, H.F. 1986: Mode of inhibitory action of gossypol on Na+, K+-ATPase in vitro Zhongguo Yao Li Xue Bao 7(3): 265-268
Bi, X.F.; Zheng, Y.J.; Liang, D.; Yang, H.F. 1984: Effects of potassium on the inhibitory effect of gossypol on Na,K-ATPase in vitro Zhongguo Yao Li Xue Bao 5(2): 115-118
Mazumder, B.; Sikdar, R.; Sen, P.C. 1991: Effect of chlorpromazine and gossypol on Ca(2+)-ATPase activity in the microsomal membranes of rat testes Indian Journal of Biochemistry and Biophysics 28(2): 136-139
Lamers, C.B. 1985: Inhibition of H+/K+-ATPase in the parietal cell with omeprazole: a new principle of gastric acid inhibition Nederlands Tijdschrift Voor Geneeskunde 129(15): 679-682
Uhlig, G.; Kolb, E.; Schineff, C. 1984: Activity and various properties of Mg-ATPase, Na,K-ATPase, Ca-ATPase and HCO3-ATPase in the kidney cortex, parotid gland and pancreas of cattle Archiv für Experimentelle Veterinarmedizin 38(4): 572-582
Ikeda, M. 1990: Inhibition kinetics of NAD-linked enzymes by gossypol acetic acid Andrologia 22(5): 409-416
Vongsorasak, L.; Svasti, J. 1985: Inhibition of liquefaction and protein degradation in human semen by gossypol International Journal of Andrology 8(6): 472-483
Wang, M.S.; Lorenzo, B.J.; Reidenberg, M.M. 1997: NAD- and NADP-dependent 11 beta-hydroxysteroid dehydrogenase isoforms in guinea pig kidney with gossypol inhibition Zhongguo Yao Li Xue Bao 18(6): 481-485
Ryes, J.; Wyrick, S.D.; Borriero, L.; Benos, D.J. 1985: The male contraceptive gossypol membrane actions of the gossypol tautomers Biophysical Journal 47(2 Part 2): 479A
Lednitskiĭ, D.G. 1977: Model studies of lateral inhibition as a mechanism of detecting motion. I. Analytic consideration of direct inhibition Biofizika 22(1): 127-132
Monosíková, R.; Breier, A.; Ziegelhöffer, A.; Sima, F. 1991: Comparison of ATP binding in the active sites of (Na+ + K(+)-ATPase, Mg(2+)-ATPase and Ca(2+)-ATPase with low affinity to calcium from cardiac sarcolemma Bratislavske Lekarske Listy 92(3-4): 142-145
Nazarenko, V.I.; Poliakova, N.M. 1976: Reversible inhibition of Na+, K+-ATPase by ouabain Ukrains'kyi Biokhimichnyi Zhurnal 48(4): 426-429
Bukatina, A.E.; Deshcherevskiĭ, V.I. 1972: Cyclic mechanism of actomyosin ATPase Biofizika 17(5): 738-743
De Smedt, H.; Paulussen-Noterman, N.; Borghgraef, R. 1979: Mechanism of the interaction of desipramine with (Na+, K+) ATPase and p-nitrophenylphosphatase Archives Internationales de Physiologie et de Biochimie 87(2): 337-339
Capuozzo, E.; Jullien, S.; Salerno, C.; Crifò, C. 1990: Inhibition of erythrocyte ghost ATPase by polyene antibiotics Biochemistry International 20(6): 1135-1139
Torlińska, T.; Grochowalska, A. 2004: Age-related changes of NA(+), K(+) - ATPase, Ca(+2) - ATPase and Mg(+2) - ATPase activities in rat brain synaptosomes Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society 55(2): 457-465
Reddy, M.S.; Rao, K.V. 1990: In vitro inhibition of Ca+2 ATPase by methylparathion in prawn: a kinetic approach Biochemistry International 22(6): 1053-1058
Schuurmans Stekhoven, F.M.; Swarts, H.G.; Lam, G.K.; Zou, Y.S.; de Pont, J.J. 1988: Phosphorylation of (Na+ + K+)-ATPase. Stimulation and inhibition by substituted and unsubstituted amines Progress in Clinical and Biological Research 268a: 355-362