The spectrum of the anticonvulsant action of morfolid
Rudometova, E.V.; Popova, N.A.; Kolla, V.E.
Eksperimental'naia i Klinicheskaia Farmakologiia 57(5): 11-13
1994
ISSN/ISBN: 0869-2092 PMID: 7696892 Document Number: 423517
The albino experiments have shown that morpholide has an anticonvulsant effect in electroshock-, corazole-, thiosemicarbazide-, bicuculline-, strychnine-, arecoline-, nicotine-, tremorine-induced convulsions and tremors. The agent has a wider range of pharmacological effects than phenobarbital. There is a higher anticonvulsant effect of morpholide combined with phenobarbital, hexamidine and diazepam. It is suggested that GABA-ergic mechanisms contribute to the anticonvulsant action of morpholide.