Novel adenosine analogues with broad-spectrum biological activity: structure and mechanism of action
Holý, A.
Nucleic Acids Symposium Series 11: 199-202
1982
ISSN/ISBN: 0261-3166 PMID: 7183960 Document Number: 192525
Aliphatic analogues of adenosine, e.g. 9-(S)-(2,3-dihydroxypropyl)adenine, its homologs and carboxy derivatives, display various biological (antiviral, aspermatogenic, chemosterilant, embryotoxic) activities. The principle in common of these effects seems to be an inhibition of SAH-hydrolase which disturbs transmethylations in rapidly proliferating systems.
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