Influence of dopaminergic receptor supersensitivity on anticonvulsant action of carbamazepine
Kadlimatti, S.H.; Nadig, R.S.; Somaja, L.; Joseph, T.; David, J.
Indian Journal of Physiology and Pharmacology 32(4): 285-288
1988
ISSN/ISBN: 0019-5499 PMID: 3215681 Document Number: 325436
Dopamine (DA) receptor supersensitivity was induced in albino rats by haloperidol (5 mg/kg, ip day, for 18 days) and after 48 hr carbamazepine (CBZ) was administered in graded doses. The animals were subjected to Maximal Electroshock Seizures (MES) test, Minimal Electroconvulsive Threshold (MET) test and Pentylenetetrazole (PTZ)-induced convulsions test. Haloperidol pretreatment marginally increased the effect of CBZ against PTZ induced seizures, buyt not against electrically induced seizures (MES and MET tests).