Oro-esophageal candidiasis resistant to fluconazole in patients with AIDS
Diz, P.; Ocampo, A.; Miralles, C.; Otero, I.; Iglesias, I.; Martínez, C.
Enfermedades Infecciosas y Microbiologia Clinica 11(1): 36-39
1993
ISSN/ISBN: 0213-005X PMID: 8461371 Document Number: 422425
Fluconazole-resistant Candida albicans has been seldom reported in the literature. in this study, two clinical cases of oro-esophageal candidosis resistant to this antifungal drug are described. Infection was confirmed by isolation of yeasts (culture of mouth swabs, oesophagoscopy and histology of biopsy specimens). In vitro antifungal susceptibility tests were performed with standard methods (NCCLS). Clinical and microbiological fluconazole-resistant Candida albicans was isolated. Causes of development of resistances are commented, and the role of immunodeficiency and the possibility of a Candida strain selection is discussed.