Genetic diversity of HLA system in two populations from Querétaro, Mexico: Querétaro city and rural Querétaro

Martínez-Álvarez, J.C.és.; Barquera, R.; Hernández-Zaragoza, D.I.íz.; Bravo-Acevedo, A.; Clayton, S.; Arrieta-Bolaños, E.; Immel, A.; Benítez-Arvizu, G.; Arrazola-García, M.ía.A.; Juárez-Barreto, V.; Vega-Martínez, M.ía.D.R.; Juárez-Nicolás, F.; Escutia-González, A.B.; Martínez-Bezies, V.; García-Álvarez, R.; Salgado-Galicia, N.; Zúñiga, J.ín.; Yunis, E.J.; Bekker-Méndez, C.; Granados, J.; Martínez-Álvarez, J.C.és; Barquera, R; Hernández-Zaragoza, D.I.íz; Bravo-Acevedo, A; Clayton, S; Arrieta-Bolaños, E; Immel, A; Benítez-Arvizu, G; Arrazola-García, M.ía.A; Juárez-Barreto, V; Vega-Martínez, M.ía.D.R; Juárez-Nicolás, F; Escutia-González, A.B; Martínez-Bezies, V; García-Álvarez, R; Salgado-Galicia, N; Zúñiga, J.ín; Yunis, E.J; Bekker-Méndez, C; Granados, J

doi:10.1016/j.humimm.2019.07.296

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Genetic diversity of HLA system in two populations from Querétaro, Mexico: Querétaro city and rural Querétaro

Martínez-Álvarez, J.C.és.; Barquera, R.; Hernández-Zaragoza, D.I.íz.; Bravo-Acevedo, A.; Clayton, S.; Arrieta-Bolaños, E.; Immel, A.; Benítez-Arvizu, G.; Arrazola-García, M.ía.A.; Juárez-Barreto, V.; Vega-Martínez, M.ía.D.R.; Juárez-Nicolás, F.; Escutia-González, A.B.; Martínez-Bezies, V.; García-Álvarez, R.; Salgado-Galicia, N.; Zúñiga, J.ín.; Yunis, E.J.; Bekker-Méndez, C.; Granados, J.

Human Immunology 81(9): 522-524

2020

ISSN/ISBN: 1879-1166

PMID: 31353129

DOI: 10.1016/j.humimm.2019.07.296

Document Number: 419477

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 88 Mexicans from the state of Querétaro living in the city of Querétaro (N = 45) and rural communities (N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Querétaro include seven Native American, two European and one Asian haplotype. Admixture estimates revealed that the main genetic components in the state of Querétaro are Native American (51.82 ± 4.42% by ML; 42.61% of Native American haplotypes) and European (48.18 ± 3.55% by ML; 46.02% of European haplotypes), with a virtually absent African genetic component (0.00 ± 4.25% by ML; 4.55% of African haplotypes).