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Genetic bases of diversity of the repertoire of immunoglobulins in application to diagnostics of clonality of B-cell lymphoid populations

Zakharova, E.S.; Kazilo, N.A.; Stefanov, D.N.; Sinitsina, M.N.; Kovrigina, A.M.

Genetika 47(6): 752-764

2011

ISSN/ISBN: 0016-6758
PMID: 21866856
Document Number: 654501
Molecular mechanisms underlying the formation of B-cell lymphomas in connection with processes associated with the maturation of B lymphocytes are reviewed. The currently used diagnostic methods do not always distinguish lymphomas from reactive changes of the lymphoid tissue. The principle of the molecular genetic method ofclonality detection in lymphocyte populations, technical problems, and the strategy of its application in clinical diagnostics of lymphomas are described in detail.

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