An experimental study of autovaccines prepared with different preservatives
Kazhina, M.V.; Pozniak, S.B.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 5: 61-65
1993
ISSN/ISBN: 0372-9311 PMID: 8067147 Document Number: 417879
The comparative study of the immunological potency of staphylococcal vaccines prepared on the basis of different preservatives the mixture of formaldehyde, glutaraldehyde and 0.5% novocaine solution in combination with Gorgiev's bactericidal fluid) was made in experiments on mice. The vaccine was prepared from three staphylococcal strains isolated from chronic tonsillitis patients. The optimum low concentrations of formaldehyde (0.025%) and glutaraldehyde (0.0125%), producing bactericidal effect on staphylococci, have been established. The vaccine prepared with the use of Gorgiev's bactericidal fluid and 0.5% novocaine solution was found to have the highest immunogenic potency. The vaccine prepared on the basis of the aldehyde mixture exhibited the lowest potency.