Pathomorphologic changes in experimental siderosis
Nazaretian, M.K.; Aĭbazian, L.K.
Arkhiv Patologii 55(1): 52-57
1993
ISSN/ISBN: 0004-1955 PMID: 7980042 Document Number: 416490
Experimental hypersiderosis was induced in rabbits by intravenous injection of iron-containing preparation Ferrum Leck. The resultant pronounced hemosiderosis was found in the liver, kidneys, heart, lungs and spleen. Dystrophic and necrotic processes arose in the liver, kidneys, heart. Accumulation of hemosiderin in the vascular walls led to their higher permeability, edema, wall thickness, proliferative changes, especially in the coronary vessels. Intravascular circulation impairment was evident from compression of microvessels by siderophages, red cells aggregation, formation of microthrombi.