Gastrojejunostomy inhibits postshunt siderosis
Doberneck, R.C.; Fischer, R.; Smith, D.
Surgery 78(3): 334-338
1975
ISSN/ISBN: 0039-6060 PMID: 1154274 Document Number: 85912
Thirteen of 14 dogs developed large increases in hepatic haemosiderin (postshunt siderosis) after construction of portacaval shunt, whereas only 3 of 12 dogs developed such siderosis after construction of a portacaval shunt and end-to-side gastrojejunostomy with duodenal exclusion. Splenic haemosiderin increased in dogs with portacaval shunt but increased minimally in dogs with portacaval shunt and gastrojejunostomy. Rib marrow fat increased slightly in dogs with portacaval shunt and decreased slightly in dogs with portacaval shunt and gastrojejunostomy. Thus continued Fe absorption appears to account for the development of postshunt siderosis and the addition of gastrojejunostomy ameliorates postshunt siderosis by diminishing Fe absorption.