Chemotherapy of destructive pulmonary tuberculosis with antioxidants and antihypoxic agents
Savula, M.M.; Kravchenko, N.S.; Poznanskiĭ, A.I.
Problemy Tuberkuleza 5: 18-20
1993
ISSN/ISBN: 0032-9533 PMID: 8295877 Document Number: 415172
The trial included 155 patients with destructive pulmonary tuberculosis: 60 on conventional antibacterial therapy (isoniazid, rifampicin, streptomycin), 95 on intensive chemotherapy (isoniazid, rifampicin, streptomycin, pirazinamid or ethambutol, vitamins for initial 2-3 months). 69 patients from the latter group received adjuvant antioxidants (tocopherol acetate or galascorbin) in combination with one of the antihypoxants (piracetam, calcii pangamas, piriditol). The intensive chemotherapy promoted a decrease in duration of bacterial discharge, destruction discontimation, cavernous healing, reduced incidence rates of side effects. Metabolic processes characterizing lipid peroxidation and redox improved.