Serum cholesterol levels of nondiabetic and streptozotocin-diabetic rats fed a high cholesterol diet
Holmgren, P.R.; Brown, A.C.
Artery 20(6): 337-345
1993
ISSN/ISBN: 0098-6127 PMID: 8010889 Document Number: 413940
The purpose of this study was to examine the effect of dietary cholesterol on the total blood cholesterol levels of nondiabetic and streptozotocin-diabetic rats. Thirty-six Sprague-Dawley rats were divided into four groups: nondiabetic/control diet (C), streptozotocin-diabetic/control diet (D), nondiabetic/control diet + 2% cholesterol (CH), and streptozotocin-diabetic/control diet + 2% cholesterol (DH). Plasma cholesterol levels were not significantly elevated in the D group (63.4 +- 9.0 mg/dl) when compared with the C group (71.3 +- 3.9 mg/dl) but were significantly higher (p lt 0.0 1) in the CH group (89.8 +- 8. 1 mg/dl). There was nearly a six-fold significant elevation (p lt 0.0025) in the DH group (530.0 +- 58. mg/dl) contrasted to the nondiabetic rats fed the same diet. The results of this study indicate that streptozotocin-diabetic rats fed a high cholesterol diet experience hypercholesterolemia.