Systemic and gastrointestinal candidiasis of infant mice as model for antifungal therapy
Ponnuvel, K.M.; Rama, C.P.; Menon, T.
Indian Journal of Experimental Biology 31(5): 450-452
1993
ISSN/ISBN: 0019-5189 PMID: 8359853 Document Number: 413928
Systemic and gastrointestinal infection was established in infant (15-19 days old) mice after oral-intragastric challenge with Candida albicans. All survivors retained high levels of organisms in the liver, kidney, spleen, stomach and intestine up to the 24th post infection day. These animals with persistent infections were used to study the efficacy of short term antifungal therapy. Drug treatment was initiated on 13th day for a two week period, treatment with fluconazole was compared with amphotericin B, and 5 fluorocytosine. The results suggest that fluconazole is a useful drug in the treatment of gastrointestinal candidiasis.