Osteoporosis by ovariectomy: calcitonin effect in an experimental model on the rat
Gnudi, S.; Giardino, R.; Mongiorgi, R.; Zati, A.; Giavaresi, G.L.; Bertocchi, G.; Gandolfi, M.G.; Avella, M.
Bollettino della Societa Italiana di Biologia Sperimentale 69(9): 563-570
1993
ISSN/ISBN: 0037-8771 PMID: 8155314 Document Number: 408150
The authors evaluate the efficacy of the aminosuberic derivative of eel calcitonin (eCT) in preventing post-ovariectomy osteoporosis in adult rats. The drug is administered in a dose of 0.5 U.I./day for four months starting from the moment of the ovariectomy. The results show that the treatment is efficacious in preventing bone mass loss due to ovariectomy and that the action of the drug does not bring about alterations in the normal crystalline structure of the bone.