Studies on osteoporoses. XII. Effect of imidazoquinazolinones on experimental osteoporosis. A preliminary report
Robin, J.C.; Ambrus, J.L.
Journal of Medicine 13(5-6): 465-472
1982
ISSN/ISBN: 0025-7850 PMID: 6963333 Document Number: 192580
In vivo neutron activation analysis was employed to determine total body calcium content in C3H/St(Ha) female mice. Ninety-nine percent of calcium is in bone and loss of calcium was used as an index of osteoporosis. Heparin (500 U/kg b.i.d.) treatment for three months resulted in significant osteoporosis. BL3459 and BL4160 (6 mg/kg i.m. q.d.) prevented this heparin induced osteoporosis. BL4160 appeared to be more effective than BL3459 in this regard but the difference was not statistically significant.