The effect of the physical status of the neutrophil membranes on their functional metabolic activity in hypertension patients
Malishevskiĭ, M.V.; Zhmurov, V.A.; Gapon, L.I.; Kashuba, E.A.; Argunova, G.A.
Kardiologiia 33(11): 13-16; 3
1993
ISSN/ISBN: 0022-9040 PMID: 8145412 Document Number: 405751
In 76 untreated patients with Stages I-II hypertensive disease, spectrophotometry with lipid specific pyrene fluorescence probe revealed higher microviscosity in the lipid phase of neutrophilic membranes, which was induced by elevated levels of cholesterol and enhanced activation of lipid peroxidation. This resulted in increased functional and metabolic neutrophilic activity which was determined by luminol-dependent zimozan-induced chemiluminescence of whole venous blood. The correlation coefficient between the microviscosity of membranes and the chemiluminescence of neutrophils is 0.82 (p).