A preliminary study on the interaction between ethanol and propranolol in normal human subjects
Chakrabarti, A.; Garg, S.K.; Sharma, P.L.
Indian Journal of Physiology and Pharmacology 36(3): 209-212
1992
ISSN/ISBN: 0019-5499 PMID: 1473855 Document Number: 404152
Ethanol significantly increased the steady-state peak concentrations of propranolol while propranolol significantly reduced the total body clearance of ethanol in healthy human volunteers. Ethanol per se caused tachycardia and rise in systolic blood pressure while propranolol administration resulted in bradycardia. In combination, ethanol and propranolol caused significant fall in diastolic blood pressure without any significant changes in the heart rate and systolic blood pressure compared to the control readings of four healthy male volunteers. The kinetic and haemodynamic interactions observed between the ethanol and propranolol in the preliminary study are of clinical relevance and need further exploration.