Oral ethanol ingestion altered nifedipine pharmacokinetics in the rat: a preliminary study
Boje, K.M.; Dolce, J.A.; Fung, H.L.
Research Communications in Chemical Pathology and Pharmacology 46(2): 219-226
1984
ISSN/ISBN: 0034-5164 PMID: 6515116 Document Number: 485
The pharmacokinetics of i.v. administered nifedipine in the presence or absence of concomitant alcohol ingestion was examined in the rat. In the presence of alcohol, the area under the nifedipine plasma concentration vs. time curve and half-life of drug elimination were increased, and the rate constant of elimination was significantly decreased (P < 0.05), while the apparent volume of distribution was apparently unaffected. Clearance, normalized to control, was significantly decreased (P < 0.01). Since nifedipine and ethanol both undergo dehydrogenation in their metabolism, it is possible that this observed drug-drug interaction may be due to a metabolic interference. It is not known at this time whether such an interaction exists in man. [Nefedipine is a calcium antagonist coronary vasodilator indicated primarily for the treatment of vasospastic and classical effort associated angina pectoris.].
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