Lipemic effects of intermittent ethanol ingestion in rats
Barboriak, J.J.; Meade, R.C.
Quarterly Journal of Studies on Alcohol 32(4): 953-959
1971
ISSN/ISBN: 0033-5649 PMID: 5137094 Document Number: 40119
Female Sprague-Dawley rats were given by stomach tube 5 g maize oil with 5 g ethanol or an isocaloric amount of glucose. The maize oil contained traces of triolein-14C. The mixtures were given for 4 consecutive days and rats were killed after the 1st, 2nd and 4th day. In a second series of experiments male rats were used and were killed before and after the 1st, 4th, 7th and 14th days; no labelled fat was used. Plasma and liver triglycerides in all rats given the maize oil and ethanol mixture for up to 14 days were significantly higher than those in rats given the maize oil and glucose mixture, although some signs of a partial adaptation to the ethanol treatment began to appear by the end of the 14-day experimental period. The rise in plasma triglycerides was associated with increasing 14C activity in the plasma, an indication that the additional lipids were mainly derived from the fat in the diet.