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Microchromatography for determination of hemoglobin a 2: statistical study of values in normal subjects and beta-thalassemic heterozygotic subjects

Izzo, P.; Corciulo, R.; Mossa, V.; Costantino, R.

Bollettino della Societa Italiana di Biologia Sperimentale 53(10): 787-791

1977

ISSN/ISBN: 0037-8771
PMID: 588346
Document Number: 110226
An improved simplified method for identifying abnormal hemoglobin (HbA2) in heterozygotic .beta.-thalassemia was reported. It is a microchromatographic method, using DE-52. The normal values (of control persons) and abnormal values for HbA2 are limited to a small range and completely separated from those with the genetically determined hemolytic anemia. Accuracy of the method was demonstrated in 2 normals and 1 thalassemic individual. Twelve tests were done on each individual. Average values and standard deviations were reported. In 9 cases of sideropenic hypochromic anemia the average value of HbA2 was 1.61%, with S.D. = 0.150. In the thalassemic case the average value for HbA2 was 4.60 .+-. 0.34 with S.D. = 0.389. The method was adaptable to determining Hb S and Hb D-Punjab, and for Hb C.

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