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Cardioprotection of ACE inhibitor in ischemic heart is not dependent on the local angiotensin Ii formation

Noda, K.; Sasaguri, M.; Ideishi, M.; Ikeda, M.; Arakawa, K.

Agents and Actions. Supplements 38: 217-227

1992

ISSN/ISBN: 0379-0363
PMID: 1462860
Document Number: 402927
Angiotensin II (AII) and bradykinin (BK) release into anterior interventricular vein (AIV) increased significantly 30 minutes after left anterior descending artery (LAD) occlusion in the absence of kidneys. Captopril enhanced BK release, but did not suppress the increase of AII release. Nafamostat suppressed both releases. Infarct size was significantly reduced by captopril but not by nafamostat. These results suggest that cardioprotective effect of captopril might be dependent on local BK accumulation, but not on suppression of local AII generation.

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