Effect of long-term angiotensin-converting enzyme inhibitor therapy on arterial oxygen saturation in patients with mild to moderate heart failure
Stanek, E.J.; Nara, A.R.; Strohl, K.P.; Nair, R.N.; Decker, M.J.; Munger, M.A.
PharmacoTherapy 14(3): 321-329
1994
ISSN/ISBN: 0277-0008 PMID: 7937273 Document Number: 431122
Study Objective. To evaluate the effects of angiotensin-converting enzyme (ACE) inhibition on continuous pulse oximetry recordings of arterial oxygen saturation (SpO-2). Design. Open-label study. Setting. Cardiology clinics at two large teaching Patients. Eight patients with New York Association Functional Class (NYHA FC) II-III heart failure. Interventions. Patients were Studied after an ACE inhibitor washout (baseline, B), and after 3 months following resumption of ACEI). Measurements and Main Results. Monitoring times for B and ACEI were approximately 22 hours. Reduction trends were observed for number (190 +- 170 vs 125 67 B vs ACEI), magnitude (8.2 +- 1.4% vs 7.5 +- 1.8%), and duration (2.45 +- 2.8 vs 1.35 +- 0.8 min) of desaturations/monitoring period, and for nadir SpO-2/desaturation (88.1 +- 1.5% 89.9 +- 3.3%). The B desaturation index ((cumulative desaturation period time) times 100, a measure of hypoxic stress or burden From 19.4 +- 8.1% to 11.9 +- 8.1% at ACEI (p=0.024). Conclusion. Long-term ACE inhibitor therapy improves the profile of SPO-2 values over time in patients With NYHA FC II-III failure.