Effects of long-term therapy with angiotensin-converting enzyme inhibitor and carvedilol on the heart remodeling process after non-Q-wave myocardial infarction
Bakaev, R.G.; Strutynskiĭ, A.V.; Kallaeva, A.N.; Glazunov, A.B.; Voronina, M.A.; Pekhtereva, D.A.; Moshkova, N.K.; Chudnovskaia, E.A.; Kochetkov, B.M.
Klinicheskaia Meditsina 89(1): 23-26
2011
ISSN/ISBN: 0023-2149 PMID: 21516760 Document Number: 650518
This 2-year comparative study of EchoCG data dynamics included 230 CHD patients after primary non-Q-wave myocardial infarction of whom 76 were treated with A CE inhibitor perindopril throughout the study period (group 1) and 72 with perindopril and carvedilol (non-selective alpha-1, beta-1,2 adrenergic receptor blocker) (group 2). The control group was comprised of 82 patients that could not use either medicine for a variety of reasons. These patients developed signs of post-infarction left ventricular remodeling (enhanced MS and LVMM index, left ventricular spherization, cavity enlargement, systolic and diastolic LF dysfunction). Combined therapy arrested the remodeling process within 12 months after onset, reduced systolic MS, and promoted the tendency toward restoration of the LV geometric shape, size, diastolic and systolic function.