Serum levels of soluble interleukin-2 receptor (sIL-2R) in B-chronic lymphocytic leukemia
Cacciola, E.; Calogero, D.; Marra, G.; Guglielmo, P.
Bollettino della Societa Italiana di Biologia Sperimentale 68(4): 259-262
1992
ISSN/ISBN: 0037-8771 PMID: 1463600 Document Number: 402732
By using an enzyme-linked immunosorbent assay, the levels of the soluble form of the interleukin-2 receptor (sIL-2R) were evaluated in the peripheral blood of 20 patients with cell chronic lymphocytic leukemia in different stages of disease and in supernatants obtained from enriched B cell suspensions. In either all serum samples or in one out of three supernatants, elevated levels of sIL-2R were found. This could indicate that the B leukemic cells release sIL-2R which in turn, for its potential capacity of binding circulating IL-2, could contribute to the abnormal immunoregulation which characterizes B-CLL. This finding, which needs further investigation, could have prognostic significance.