Serum soluble CD8 and soluble interleukin-2-receptor levels during interferon therapy in chronic hepatitis C
Maekawa, H.; Ishiyama, N.; Furuya, N.; Nakahara, K.; Saito, S.; Uchimura, H.
Rinsho Byori. Japanese Journal of Clinical Pathology 45(10): 1003-1007
1997
ISSN/ISBN: 0047-1860 PMID: 9369080 Document Number: 483124
We examined the relationship between the changes of serum soluble CD8 (sCD8) and soluble interleukin-2 receptor (sIL-2R) levels and effectiveness of interferon (IFN) in patients with chronic hepatitis (CH) C. Changes in sCD8 levels were parallel with fluctuations of alanine aminotransferase (ALT) in CH patients during IFN treatment but decreases of sCD8 levels were slower than those of ALT. In IFN effective and ALT decreased patients sCD8 levels is also decreased. sIL-2R levels was increased transiently during administration of IFN in most cases. It was suggested that decrease in sCD8 levels is indicative of the effectiveness of IFN therapy.