High serum levels of soluble interleukin-2 receptors in sarcoidosis
Semenzato, G.; Cipriani, A.; Trentin, L.; Zambello, R.; Masciarelli, M.; Vinante, F.; Chilosi, M.; Pizzolo, G.
Sarcoidosis 4(1): 25-27
1987
ISSN/ISBN: 0393-1447 PMID: 3108983 Document Number: 293181
We provide evidence that high levels of soluble interleukin-2 receptor (sIL-2R) are present in the serum of patients with sarcoidosis. Because sIL-2R is capable of binding to its ligand (IL-2), the increased serum levels of this molecule could induce a starvation of IL-2. This mechanism could help to explain a number of immunological abnormalities extensively reported in these patients and generally attributed to not yet identified serum inhibitory factors.
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