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Change in the structural state of fractionated liver chromatin in E vitamin deficiency

Gubskiĭ, I.I.; Levitskiĭ, E.L.; Primak, R.G.

Ukrainskii Biokhimicheskii Zhurnal 64(5): 86-89

1992

ISSN/ISBN: 0201-8470
PMID: 1462376
Document Number: 402144
Structural modification of transcriptionally active and repressed rat liver chromatin fractions at antioxidant insufficiency caused by E-avitaminosis, was shown. This modification consisted in the compactization of the first fraction structure and in the relaxation of the second one. Besides, compactization of the active fraction structure was accompanied with the increase of fluidity of the lipid bilayer. On the whole antioxidant insufficiency caused more expressed structural changes in the active chromatin fraction, this correlated with the intensity of lipid peroxidation reactions in the fractions.

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