Effects of anticonvulsant drugs on thyroid hormones in epileptic children
Deda, G.; Akinci, A.; Teziç, T.; Karagöl, U.
Turkish Journal of Pediatrics 34(4): 239-244
1992
ISSN/ISBN: 0041-4301 PMID: 1306344 Document Number: 400850
Serum total and free thyroid hormones, reverse T3 (rT3), thyroxin binding globulin (TBG) and thyroid stimulating hormone (TSH) concentrations were measured in 35 epileptic patients receiving anticonvulsants (phenobarbitone, phenytoin). There was a significant reduction found in total thyroxine (TT4), free thyroxine (FT4), total triiodothyronine (TT3), free triiodothyronine (FT3) and rT3 in the group treated with, phenytoin. The thyroid hormone levels were within normal limits in the group receiving phenobarbitone.